Twitter user Joshua Nelson wrote"A few houses down the propeller and engine landed in their yard
The small plane crashed shortly after departing from the Fullerton Municipal Airport, an FAA spokesman told local media.
Pokey Sanchez, an assistant chief with the Orange County Fire Department, said firefighters planned to sift through the badly burned two-story house in case there are additional victims of the Sunday afternoon crash.
Someone else wrote: "Plane crashed near my house in Yorba Linda".
Images posted by witnesses seem to show at least two homes on fire.
Authorities say two people were also injured.
The aircraft involved was a Cessna 414A Chancellor, an 8-seat twin-engine plane.
Alonso becomes 3rd Formula 1 champ to win Rolex 24 at Daytona
Despite officials' best efforts to resume racing, the cars didn't return to the track and the No.10 Cadillac triumphed. We stayed out of trouble, no vehicle damage, no one went off the track.
In a video from the crash scene which was shot at about 3pm, one of the residences can be seen having been destroyed by the fire.
The injured people were said to have suffered burns, although their condition is unknown, according to ABC 7. "The number of people on board the aircraft is not presently known".
An investigation by the National Transportation Safety Board is ongoing.
It is not clear how many people were onboard the plane when it came down.
Pat Rogers, who lives about a mile from the crash site, told the Orange County Register he saw the plane on fire and coming apart.
In footage from one of the neighbourhood's residents, loud gun-shot like noises can be heard as bystanders yell out to "move away" from the house which is well engulfed in flames.
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